The American branch of SHIELD, UNCLE is a federal enforcement agency designed to handle those threats and crimes that are beyond the scope of normal law enforcement. From super-villains to advanced terrorist organizations, UNCLE's well-trained personnel, armed with high-tech weaponry, stand ready to defend the nation from any threat--foreign, domestic, alien or inter-dimensional.

UNCLE's San Francisco branch was, for years, a dumping ground for problem agents. When Sydney Todd-Strange (formerly Forte's Mist) was given her own command, she was sent there to whip things into shape. Still given questionable personnel and sub-standard resources, she managed to turn things around and build a successful and dedicated branch despite the limitations she faced. Her work there was severely tested as things began to come apart in San Francisco, with villains, terrorists, cults and organized crime moving in on a city without a super-hero presence. The creation of her new hero team--Forge--has taken a large burden off UNCLE's personnel, but they're still on the battlefield each day, keeping their city safe and free.